Novel Candidate for HIV Neuroprotection Macrophage-Mediated Neurotoxicity: A Suppresses HIV Replication and and Inducer of the Antioxidant Response, Dimethyl Fumarate, an Immune Modulator
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منابع مشابه
Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection.
Despite antiretroviral therapy (ART), HIV infection promotes cognitive dysfunction and neurodegeneration through persistent inflammation and neurotoxin release from infected and/or activated macrophages/microglia. Furthermore, inflammation and immune activation within both the CNS and periphery correlate with disease progression and morbidity in ART-treated individuals. Accordingly, drugs targe...
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